Clinical significance of vascular endothelial growth factor and hepatocyte growth factor in multiple myeloma

Angiogenesis is a crucial process in the progression of multiple myeloma (MM). Vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) are multifunctional cytokines that potently stimulate angiogenesis including tumour neovascularization. Serum levels of VEGF and HGF were measur...

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Veröffentlicht in:	British journal of haematology 2002-03, Vol.116 (4), p.796-802
Hauptverfasser:	Iwasaki, Tsuyoshi, Hamano, Teruaki, Ogata, Atsushi, Hashimoto, Naoaki, Kitano, Masayasu, Kakishita, Eizo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over amyloidosis Amyloidosis - blood Amyloidosis - drug therapy Amyloidosis - urine Biological and medical sciences Biomarkers - blood Biomarkers - urine Case-Control Studies Disease Progression Endothelial Growth Factors - blood Endothelial Growth Factors - urine Enzyme-Linked Immunosorbent Assay - methods extramedullary plasmacytoma Female hepatocyte growth factor Hepatocyte Growth Factor - blood Hepatocyte Growth Factor - urine Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Lymphokines - blood Lymphokines - urine Male Medical sciences Middle Aged multiple myeloma Multiple Myeloma - blood Multiple Myeloma - drug therapy Multiple Myeloma - urine Myeloma Proteins - analysis Myeloma Proteins - urine Plasmacytoma - blood Plasmacytoma - drug therapy Plasmacytoma - urine Survival Analysis Treatment Failure vascular endothelial growth factor Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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Zusammenfassung:	Angiogenesis is a crucial process in the progression of multiple myeloma (MM). Vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) are multifunctional cytokines that potently stimulate angiogenesis including tumour neovascularization. Serum levels of VEGF and HGF were measured in 52 patients with MM by enzyme‐linked immunosorbent assay (ELISA). Serum levels of VEGF and HGF were elevated in MM patients compared with healthy controls (VEGF: mean 0·31 ng/ml and 0·08 ng/ml respectively, P
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.0007-1048.2002.03364.x