Role of substance P in the peripheral vestibular and auditory system

The central role of substance P (SP) has attracted growing interest in the past two decades. One of the important physiological functions of SP and other tachykinins is that of a neurotransmitter in primary afferent neurons. Recent immunocytochemical, biochemical and electrophysiological investigati...

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Veröffentlicht in:	Advances in oto-rhino-laryngology 2002, Vol.59, p.26-34
Hauptverfasser:	Felix, H, Oestreicher, E, Felix, D, Ehrenberger, K
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - metabolism Auditory Cortex - metabolism Auditory Cortex - physiology Cochlea - physiology Hair Cells, Auditory, Inner - metabolism Hair Cells, Auditory, Inner - ultrastructure Humans N-Methylaspartate - metabolism Substance P - metabolism Substance P - physiology Vestibular Nerve - metabolism Vestibular Nerve - ultrastructure Vestibule, Labyrinth - metabolism Vestibule, Labyrinth - physiology
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Beschreibung
Zusammenfassung:	The central role of substance P (SP) has attracted growing interest in the past two decades. One of the important physiological functions of SP and other tachykinins is that of a neurotransmitter in primary afferent neurons. Recent immunocytochemical, biochemical and electrophysiological investigations on various neurotransmitters support the hypothesis that SP has a similar function in the vestibular and auditory systems of all mammals including humans. The purpose of this review is to give an overview of the distribution and concomitant physiological functions of this peptide in these sensory systems.
ISSN:	0065-3071
DOI:	10.1159/000059239