Stereocontrolled Total Synthesis of (+)-Vinblastine

Stereocontrolled Total Synthesis of (+)-Vinblastine

A stereocontrolled total synthesis of (+)-vinblastine was accomplished, featuring preparations of the two indole units by means of a novel indole synthesis via radical cyclization of thioanilide, and a stereoselective coupling of these units.

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Veröffentlicht in:Journal of the American Chemical Society 2002-03, Vol.124 (10), p.2137-2139
Hauptverfasser: Yokoshima, Satoshi, Ueda, Toshihiro, Kobayashi, Satoshi, Sato, Ayato, Kuboyama, Takeshi, Tokuyama, Hidetoshi, Fukuyama, Tohru
Format: Artikel
Sprache:eng
Schlagworte:
Alicyclic compounds, terpenoids, prostaglandins, steroids
Antineoplastic Agents, Phytogenic - chemical synthesis
Catharanthus - chemistry
Chemistry
Exact sciences and technology
Organic chemistry
Preparations and properties
Stereoisomerism
Steroids
Vinblastine - chemical synthesis
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Beschreibung
Zusammenfassung:A stereocontrolled total synthesis of (+)-vinblastine was accomplished, featuring preparations of the two indole units by means of a novel indole synthesis via radical cyclization of thioanilide, and a stereoselective coupling of these units.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja0177049