Macrocyclic diterpenes from Euphorbia nivulia

The latex of Euphorbia nivulia afforded two ingol diterpenes 3,12-diacetyl-8-benzoylingol (4) and 3,12-diacetyl-7-benzoyl-8-nicotinylingol (5) along with three known ingol diterpenes 1, 2,and 3, and two known triterpenes cycloart-25-en-3beta-ol and cyclonivulinol. Their structures have been assigned...

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Veröffentlicht in:	Phytochemistry (Oxford) 2002-02, Vol.59 (3), p.331-335
Hauptverfasser:	RAVIKANTH, V, NIRANJAN REDDY, V. L, PRABHAKAR RAO, T, DIWAN, P. V, RAMAKRISHNA, S, VENKATESWARLU, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemical constitution Dinoprostone - antagonists & inhibitors Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Euphorbia - chemistry Fundamental and applied biological sciences. Psychology General pharmacology Humans Magnetic Resonance Spectroscopy Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant physiology and development Triterpenes - chemistry Triterpenes - isolation & purification
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Zusammenfassung:	The latex of Euphorbia nivulia afforded two ingol diterpenes 3,12-diacetyl-8-benzoylingol (4) and 3,12-diacetyl-7-benzoyl-8-nicotinylingol (5) along with three known ingol diterpenes 1, 2,and 3, and two known triterpenes cycloart-25-en-3beta-ol and cyclonivulinol. Their structures have been assigned on the basis of their structural data as well as their acetylated products. The diterpenes 1-5 were tested for the LPS induced PGE(2) inhibition activity.
ISSN:	0031-9422 1873-3700
DOI:	10.1016/S0031-9422(01)00461-7