Optically Active Cyclic Hexapeptides with Covalently Attached Pyrene Probes: Selective Alkaline Earth Metal Ion Recognition Using Excimer Emission

The synthesis of two optically active pyrene-modified cyclic hexapetides and their selectivity toward the complexation of alkaline earth metal ions are reported. Complexation was studied by optical and chiroptical methods. The cyclic peptides are forming 2:1 sandwich complexes with the metal ions.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2002-03, Vol.4 (5), p.683-686
Hauptverfasser:	Strauss, Jörg, Daub, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - analysis Calcium - chemistry Calcium - metabolism Fluorescent Dyes - chemistry Metals, Alkaline Earth - analysis Metals, Alkaline Earth - chemistry Metals, Alkaline Earth - metabolism Models, Molecular Molecular Probes - chemistry Oligopeptides - chemistry Oligopeptides - metabolism Optical Rotation Peptides, Cyclic - chemistry Peptides, Cyclic - metabolism Pyrenes - chemistry Spectrometry, Fluorescence Titrimetry
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Beschreibung
Zusammenfassung:	The synthesis of two optically active pyrene-modified cyclic hexapetides and their selectivity toward the complexation of alkaline earth metal ions are reported. Complexation was studied by optical and chiroptical methods. The cyclic peptides are forming 2:1 sandwich complexes with the metal ions.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol0170354