Malformations of cortical development in neurofibromatosis type 1

The authors report three patients with neurofibromatosis type 1 and different types of malformations of cortical development: Patient 1 had a possible transmantle cortical dysplasia involving the right temporoinsuloparieto-occipital areas; Patient 2 had a periventricular band of heterotopic gray mat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurology 2003-12, Vol.61 (12), p.1799-1801
Hauptverfasser:	BALESTRI, P, VIVARELLI, R, GROSSO, S, SANTORI, L, FARNETANI, M. A, GALLUZZI, P, VATTI, G. P, CALABRESE, F, MORGESE, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Cerebral Cortex - abnormalities Cerebral Cortex - pathology Child, Preschool Developmental Disabilities - etiology Electroencephalography Female Humans Intellectual Disability - etiology Magnetic Resonance Imaging Male Medical sciences Nervous System Malformations - complications Nervous System Malformations - diagnosis Neurofibromatosis 1 - complications Neurofibromatosis 1 - diagnosis Neurology Seizures - etiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The authors report three patients with neurofibromatosis type 1 and different types of malformations of cortical development: Patient 1 had a possible transmantle cortical dysplasia involving the right temporoinsuloparieto-occipital areas; Patient 2 had a periventricular band of heterotopic gray matter with an overlying pachygyric cerebral cortex; and Patient 3 had a left perisylvian polymicrogyria. Because all of these lesions result from different pathogenetic mechanisms, neurofibromin may play a role during several stages of cortical development.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.WNL.0000099080.90726.BA