Facile Access to Optically Active Labdane-Type Diterpenes from (+)-Manool. Synthesis of (+)-Coronarin E, (+)-15,16-Epoxy-8(17),13(16),14-labdatriene, and (+)-Labda-8(17),13(Z)-diene-15,16-diol

Facile Access to Optically Active Labdane-Type Diterpenes from (+)-Manool. Synthesis of (+)-Coronarin E, (+)-15,16-Epoxy-8(17),13(16),14-labdatriene, and (+)-Labda-8(17),13(Z)-diene-15,16-diol

An efficient method for the synthesis of (+)-coronarin E (1), (+)-15,16-epoxy-8(17),13(16),14-labdatriene (2), and (+)-labda-8(17),13(Z)-diene-15,16-diol (3) from (+)-manool is described.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2003-12, Vol.66 (12), p.1623-1627
Hauptverfasser: Villamizar, José, Fuentes, Juan, Salazar, Franklin, Tropper, Eleonora, Alonso, Randolph
Format: Artikel
Sprache:eng
Schlagworte:
Alicyclic compounds, terpenoids, prostaglandins, steroids
Catalysis
Chemistry
Diterpenes - chemical synthesis
Diterpenes - chemistry
Exact sciences and technology
Indicators and Reagents
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Organic chemistry
Oxidation-Reduction
Preparations and properties
Stereoisomerism
Terpenoids
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Zusammenfassung:An efficient method for the synthesis of (+)-coronarin E (1), (+)-15,16-epoxy-8(17),13(16),14-labdatriene (2), and (+)-labda-8(17),13(Z)-diene-15,16-diol (3) from (+)-manool is described.
ISSN:0163-3864
1520-6025
DOI:10.1021/np030166o