Monoamine Oxidase Inhibitory Coumarin from Zanthoxylum schinifolium

Monoamine Oxidase Inhibitory Coumarin from Zanthoxylum schinifolium

Abstract A methanol extract of ZANTHOXYLUM SCHINIFOLIUM stems at a concentration of 250 μg/ml showed potent inhibitory activity against monoamine oxidase (MAO) in a mouse brain. Activity-guided separation and purification of the extract yielded lacinartin (1) as an active coumarin compound. Lacinart...

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Veröffentlicht in:Planta medica 2002, Vol.68 (1), p.84-85
Hauptverfasser: Jo, Young Su, Huong, Dang Thi, Bae, KiHwan, Lee, Myung Koo, Kim, Young Ho
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Brain - enzymology
Coumarins - chemistry
Coumarins - isolation & purification
Coumarins - pharmacology
Dose-Response Relationship, Drug
General pharmacology
Kinetics
Letter
Male
Medical sciences
Mice
Monoamine Oxidase - drug effects
Monoamine Oxidase - metabolism
Monoamine Oxidase Inhibitors - chemistry
Monoamine Oxidase Inhibitors - isolation & purification
Monoamine Oxidase Inhibitors - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Rutaceae
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Zusammenfassung:Abstract A methanol extract of ZANTHOXYLUM SCHINIFOLIUM stems at a concentration of 250 μg/ml showed potent inhibitory activity against monoamine oxidase (MAO) in a mouse brain. Activity-guided separation and purification of the extract yielded lacinartin (1) as an active coumarin compound. Lacinartin showed significant inhibitory effects on MAO in a dose-dependent manner. The IC 50 value on MAO activity was 9.2μM. The MAO-A (IC 50 value, 5.7 μM) sensitivity to lacinartin was greater than that of MAO-B (IC 50 value, 28.6μM). An enzyme kinetic study revealed that lacinartin inhibited MAO activity by a non-competitive mode.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2002-20056