Stereospecific synthesis of (+)-oxybiotin from d-xylose

Stereospecific synthesis of (+)-oxybiotin from d-xylose

A new 14-step synthesis of (+)-oxybiotin, an oxygen analogue of (+)-biotin, was achieved starting from d-xylose by use of selected 2,5-anhydro sugar derivatives as key intermediates. Graphic

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Veröffentlicht in:Carbohydrate research 2002-03, Vol.337 (5), p.459-465
Hauptverfasser: Popsavin, Velimir, Benedeković, Goran, Popsavin, Mirjana, Miljković, Dušan
Format: Artikel
Sprache:eng
Schlagworte:
(+)-Oxybiotin
2,3,4-Trisubstituted tetrahydrofuranes
Biotin - analogs & derivatives
Biotin - chemical synthesis
Biotin - chemistry
d-Xylose
Molecular Conformation
Protected 2,5-anhydro pentoses
Xylose - chemistry
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Beschreibung
Zusammenfassung:A new 14-step synthesis of (+)-oxybiotin, an oxygen analogue of (+)-biotin, was achieved starting from d-xylose by use of selected 2,5-anhydro sugar derivatives as key intermediates. Graphic
ISSN:0008-6215
1873-426X
DOI:10.1016/S0008-6215(01)00331-7