SHORT REPORT: REQUIREMENT OF B CELLS FOR DELAYED TYPE HYPERSENSITIVITY-LIKE PATHOLOGY AFTER SECONDARY INFECTION WITH LEISHMANIA MAJOR IN RESISTANT C57BL/6 MICE
B cell-deficient C57B1/6 (microMT) mice were resistant to Leishmania major after both primary and secondary parasite challenge. However, unlike in wild-type mice, secondary infection in microMT mice was not accompanied by a marked delayed type hypersensitivity-like response, and interferon-gamma (IF...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2003-11, Vol.69 (5), p.481-483 |
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| container_end_page | 483 |
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| container_issue | 5 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | DEKREY, GREGORY K JONES, JEREMY J MBOW, M. LAMINE BRODSKYN, CLAUDIA I TITUS, RICHARD G |
| description | B cell-deficient C57B1/6 (microMT) mice were resistant to Leishmania major after both primary and secondary parasite challenge. However, unlike in wild-type mice, secondary infection in microMT mice was not accompanied by a marked delayed type hypersensitivity-like response, and interferon-gamma (IFN-gamma) levels were approximately half of those in wild-type mice. These results suggest that B cells are involved in IFN-gamma production and the pathology of secondary infection. |
| doi_str_mv | 10.4269/ajtmh.2003.69.481 |
| format | Article |
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These results suggest that B cells are involved in IFN-gamma production and the pathology of secondary infection.</description><subject>Animals</subject><subject>B-Lymphocytes - immunology</subject><subject>Female</subject><subject>Hypersensitivity, Delayed - pathology</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Leishmania major - immunology</subject><subject>Leishmaniasis, Cutaneous - immunology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUFvmzAcxa1qU5t1_QC7TL6sN1IbDI53c4kZ3gik4G7iZBFillSwdDhRtE-zrzq3ibSLnyz93nvS_wHwAaMp8SN21zzth83URyiYRmxKZvgCTDChkYcjEr4BE4SQ77EooFfgnbVPCOGZj_EluMIkYiGakQn4W6VFqWAplk4-O314lKVYiFzBIoH3MBZZVsGkKOFcZLwWc6jqpYCpe8pK5JVU8rtUtZfJbwIuuUqLrPhSQ54oUcJKxEU-52UNZZ6IWMkihz-kSmEmZJUueC45XPCvLlzmrrqSleKuOA7pfXYXwYWMxXvwtmt6a27Oeg0eE6Hi1HM1MuaZ1wYU7b2gJT4NWecHPqYNQ7QNWEQjSklHsCGENiZAzLBmRsNViJsOEbNehR3x2Roj0gbX4PaU-zzufh-M3etha1vT980vsztYTbE7L6PUgfgEtuPO2tF0-nncDs34R2OkX1bRr6vol1W0-zmb83w8hx9Wg1n_d5xncMCnE7DZ_twct6PRdmj63uFYH49HFxO-Bv0DfI2JSQ</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>DEKREY, GREGORY K</creator><creator>JONES, JEREMY J</creator><creator>MBOW, M. 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| identifier | ISSN: 0002-9637 |
| ispartof | The American journal of tropical medicine and hygiene, 2003-11, Vol.69 (5), p.481-483 |
| issn | 0002-9637 1476-1645 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals B-Lymphocytes - immunology Female Hypersensitivity, Delayed - pathology Interferon-gamma - biosynthesis Leishmania major - immunology Leishmaniasis, Cutaneous - immunology Mice Mice, Inbred C57BL Mice, Knockout |
| title | SHORT REPORT: REQUIREMENT OF B CELLS FOR DELAYED TYPE HYPERSENSITIVITY-LIKE PATHOLOGY AFTER SECONDARY INFECTION WITH LEISHMANIA MAJOR IN RESISTANT C57BL/6 MICE |
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