SHORT REPORT: REQUIREMENT OF B CELLS FOR DELAYED TYPE HYPERSENSITIVITY-LIKE PATHOLOGY AFTER SECONDARY INFECTION WITH LEISHMANIA MAJOR IN RESISTANT C57BL/6 MICE
B cell-deficient C57B1/6 (microMT) mice were resistant to Leishmania major after both primary and secondary parasite challenge. However, unlike in wild-type mice, secondary infection in microMT mice was not accompanied by a marked delayed type hypersensitivity-like response, and interferon-gamma (IF...
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Veröffentlicht in: | The American journal of tropical medicine and hygiene 2003-11, Vol.69 (5), p.481-483 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | B cell-deficient C57B1/6 (microMT) mice were resistant to Leishmania major after both primary and secondary parasite challenge. However, unlike in wild-type mice, secondary infection in microMT mice was not accompanied by a marked delayed type hypersensitivity-like response, and interferon-gamma (IFN-gamma) levels were approximately half of those in wild-type mice. These results suggest that B cells are involved in IFN-gamma production and the pathology of secondary infection. |
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ISSN: | 0002-9637 1476-1645 |
DOI: | 10.4269/ajtmh.2003.69.481 |