BAFFled B cells survive and thrive: roles of BAFF in B-cell development
Interactions of BAFF (B-cell activating factor) with BAFF-R, one of three BAFF-binding receptors that are preferentially expressed on B cells, are essential for B-cell development, because defects in either the ligand or the receptor arrest progression from immature type-1 B cells to type-2 cells an...
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| Veröffentlicht in: | Current opinion in immunology 2002-04, Vol.14 (2), p.266-275 |
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| creator | Rolink, Antonius G Melchers, Fritz |
| description | Interactions of BAFF (B-cell activating factor) with BAFF-R, one of three BAFF-binding receptors that are preferentially expressed on B cells, are essential for B-cell development, because defects in either the ligand or the receptor arrest progression from immature type-1 B cells to type-2 cells and mature cells; B1 B cells are unaffected. Transgenic BAFF overexpression leads to B-cell hyperplasia and autoimmune disease.
In vitro, BAFF increases survival of immature and mature B cells; immature B cells also mature polyclonally to mature B cells, without proliferation. Upon BAFF-influenced differentiation, immature B cells change their surface-IgM signal transduction machinery and proliferate rather than undergoing apoptosis.
BAFF has emerged as a critical regulator of B-cell development and survival. It is also involved in autoimmune responses. |
| doi_str_mv | 10.1016/S0952-7915(02)00332-1 |
| format | Article |
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In vitro, BAFF increases survival of immature and mature B cells; immature B cells also mature polyclonally to mature B cells, without proliferation. Upon BAFF-influenced differentiation, immature B cells change their surface-IgM signal transduction machinery and proliferate rather than undergoing apoptosis.
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In vitro, BAFF increases survival of immature and mature B cells; immature B cells also mature polyclonally to mature B cells, without proliferation. Upon BAFF-influenced differentiation, immature B cells change their surface-IgM signal transduction machinery and proliferate rather than undergoing apoptosis.
BAFF has emerged as a critical regulator of B-cell development and survival. It is also involved in autoimmune responses.</description><subject>Animals</subject><subject>APRIL</subject><subject>B cell</subject><subject>B-Cell Activating Factor</subject><subject>B-Cell Activation Factor Receptor</subject><subject>B-Cell Maturation Antigen</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - physiology</subject><subject>BAFF</subject><subject>BAFF protein</subject><subject>BCMA</subject><subject>Cell Lineage - physiology</subject><subject>development</subject><subject>Immunoglobulins - physiology</subject><subject>Membrane Proteins - physiology</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Neuropeptides - physiology</subject><subject>Nuclear Proteins - physiology</subject><subject>Receptors, Tumor Necrosis Factor - physiology</subject><subject>TACI</subject><subject>Transmembrane Activator and CAML Interactor Protein</subject><subject>Tumor Necrosis Factor-alpha - physiology</subject><issn>0952-7915</issn><issn>1879-0372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLFOwzAQhi0EoqXwCCBPCIbA2Y7jmAW1FS1IlRiA2UriswhKk2KnlXh7kraCsdPd8P33nz5CLhncMWDJ_RtoySOlmbwBfgsgBI_YERmyVOkIhOLHZPiHDMhZCF8AIKWAUzJgLE20BjEk88l4NqvQ0gktsKoCDWu_KTdIs9rS9tN36wP1TYWBNo72MC1rOol6mFrcYNWslli35-TEZVXAi_0ckY_Z0_v0OVq8zl-m40VUCFBtlOcSnXNMWKm4Ay4zzTVwl9pM2MRqQAlaMaWUy3mGibRpgajymLkiTmUuRuR6d3flm-81htYsy9A_k9XYrINRLE6ZiOVBkKUCBCQ9KHdg4ZsQPDqz8uUy8z-GgelVm61q03s0wM1WtWFd7mpfsM6XaP9Te7cd8LgDsPOxKdGbUJRYF2hLj0VrbFMeqPgF-QaL0w</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Rolink, Antonius G</creator><creator>Melchers, Fritz</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>BAFFled B cells survive and thrive: roles of BAFF in B-cell development</title><author>Rolink, Antonius G ; Melchers, Fritz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-bb5efff13d572f025a92902f8da3d6d90e50971777fb2ae65d8cee7b41fc485b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>APRIL</topic><topic>B cell</topic><topic>B-Cell Activating Factor</topic><topic>B-Cell Activation Factor Receptor</topic><topic>B-Cell Maturation Antigen</topic><topic>B-Lymphocytes - cytology</topic><topic>B-Lymphocytes - physiology</topic><topic>BAFF</topic><topic>BAFF protein</topic><topic>BCMA</topic><topic>Cell Lineage - physiology</topic><topic>development</topic><topic>Immunoglobulins - physiology</topic><topic>Membrane Proteins - physiology</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Neuropeptides - physiology</topic><topic>Nuclear Proteins - physiology</topic><topic>Receptors, Tumor Necrosis Factor - physiology</topic><topic>TACI</topic><topic>Transmembrane Activator and CAML Interactor Protein</topic><topic>Tumor Necrosis Factor-alpha - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rolink, Antonius G</creatorcontrib><creatorcontrib>Melchers, Fritz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rolink, Antonius G</au><au>Melchers, Fritz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BAFFled B cells survive and thrive: roles of BAFF in B-cell development</atitle><jtitle>Current opinion in immunology</jtitle><addtitle>Curr Opin Immunol</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>14</volume><issue>2</issue><spage>266</spage><epage>275</epage><pages>266-275</pages><issn>0952-7915</issn><eissn>1879-0372</eissn><abstract>Interactions of BAFF (B-cell activating factor) with BAFF-R, one of three BAFF-binding receptors that are preferentially expressed on B cells, are essential for B-cell development, because defects in either the ligand or the receptor arrest progression from immature type-1 B cells to type-2 cells and mature cells; B1 B cells are unaffected. Transgenic BAFF overexpression leads to B-cell hyperplasia and autoimmune disease.
In vitro, BAFF increases survival of immature and mature B cells; immature B cells also mature polyclonally to mature B cells, without proliferation. Upon BAFF-influenced differentiation, immature B cells change their surface-IgM signal transduction machinery and proliferate rather than undergoing apoptosis.
BAFF has emerged as a critical regulator of B-cell development and survival. It is also involved in autoimmune responses.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>11869903</pmid><doi>10.1016/S0952-7915(02)00332-1</doi><tpages>10</tpages></addata></record> |
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| ispartof | Current opinion in immunology, 2002-04, Vol.14 (2), p.266-275 |
| issn | 0952-7915 1879-0372 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals APRIL B cell B-Cell Activating Factor B-Cell Activation Factor Receptor B-Cell Maturation Antigen B-Lymphocytes - cytology B-Lymphocytes - physiology BAFF BAFF protein BCMA Cell Lineage - physiology development Immunoglobulins - physiology Membrane Proteins - physiology Mice Mice, Transgenic Neuropeptides - physiology Nuclear Proteins - physiology Receptors, Tumor Necrosis Factor - physiology TACI Transmembrane Activator and CAML Interactor Protein Tumor Necrosis Factor-alpha - physiology |
| title | BAFFled B cells survive and thrive: roles of BAFF in B-cell development |
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