BAFFled B cells survive and thrive: roles of BAFF in B-cell development

Interactions of BAFF (B-cell activating factor) with BAFF-R, one of three BAFF-binding receptors that are preferentially expressed on B cells, are essential for B-cell development, because defects in either the ligand or the receptor arrest progression from immature type-1 B cells to type-2 cells an...

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Veröffentlicht in:Current opinion in immunology 2002-04, Vol.14 (2), p.266-275
Hauptverfasser: Rolink, Antonius G, Melchers, Fritz
Format: Artikel
Sprache:eng
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Zusammenfassung:Interactions of BAFF (B-cell activating factor) with BAFF-R, one of three BAFF-binding receptors that are preferentially expressed on B cells, are essential for B-cell development, because defects in either the ligand or the receptor arrest progression from immature type-1 B cells to type-2 cells and mature cells; B1 B cells are unaffected. Transgenic BAFF overexpression leads to B-cell hyperplasia and autoimmune disease. In vitro, BAFF increases survival of immature and mature B cells; immature B cells also mature polyclonally to mature B cells, without proliferation. Upon BAFF-influenced differentiation, immature B cells change their surface-IgM signal transduction machinery and proliferate rather than undergoing apoptosis. BAFF has emerged as a critical regulator of B-cell development and survival. It is also involved in autoimmune responses.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(02)00332-1