Tuberculosis and Treatment with Infliximab

To the Editor: In support of the findings of Keane et al. (Oct. 11 issue), 1 we describe the reactivation of latent tuberculosis in a 19-year-old Pakistani man treated with infliximab for sight-threatening uveitis of unknown cause despite extensive investigation. The patient presented with a 3-week history of fever, sweats, dry cough, and breathlessness 60 days after the first of three intravenous boluses of infliximab at a dose of 5 mg per kilogram of body weight. Upper and midzone interstitial lung shadowing and extensive lymphadenopathy were noted on computed tomographic scanning. Lymph-node biopsy revealed heavy infiltration with acid-fast bacilli. The patient's . . .