Circulating matrix metalloproteinase-1 and -3 in patients with an acute coronary syndrome

To elucidate the diagnostic value of serum matrix metalloproteinase (MMP) levels, we measured MMP-1 and MMP-3 by a 1-step sandwich enzyme immunoassay. The transcardiac gradients of both MMPs were greater in patients with unstable angina and acute myocardial infarction than in patients with stable ef...

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Veröffentlicht in:	The American journal of cardiology 2003-12, Vol.92 (12), p.1461-1464
Hauptverfasser:	Inoue, Teruo, Kato, Toru, Takayanagi, Kan, Uchida, Toshihiko, Yaguchi, Isao, Kamishirado, Hirotoshi, Morooka, Shigenori, Yoshimoto, Nobuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Angina Pectoris - blood Angina, Unstable - blood Biological and medical sciences Biomarkers - blood Cardiology. Vascular system Cardiovascular disease Case-Control Studies Coronary Angiography Coronary heart disease Female Heart Humans Immunoenzyme Techniques Male Matrix Matrix Metalloproteinase 1 - blood Matrix Metalloproteinase 3 - blood Medical sciences Middle Aged Myocardial Infarction - blood Proteins Tissue Inhibitor of Metalloproteinase-1 - blood
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Beschreibung
Zusammenfassung:	To elucidate the diagnostic value of serum matrix metalloproteinase (MMP) levels, we measured MMP-1 and MMP-3 by a 1-step sandwich enzyme immunoassay. The transcardiac gradients of both MMPs were greater in patients with unstable angina and acute myocardial infarction than in patients with stable effort angina or control patients. Serum MMP levels appear to be a marker of plaque instability in patients with acute coronary syndrome.
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2003.08.061