Strategies for Heterocyclic Construction via Novel Multicomponent Reactions Based on Isocyanides and Nucleophilic Carbenes

Strategies for Heterocyclic Construction via Novel Multicomponent Reactions Based on Isocyanides and Nucleophilic Carbenes

This Account focuses mainly on our recent endeavors in the area of multicomponent reactions (MCRs) involving zwitterionic species generated by the addition of isocyanides and nucleophilic carbenes such as dimethoxycarbene and N-heterocyclic carbenes to activated alkynes. The strategy employed encomp...

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Veröffentlicht in:Accounts of chemical research 2003-12, Vol.36 (12), p.899-907
Hauptverfasser: Nair, Vijay, Rajesh, C, Vinod, A. U, Bindu, S, Sreekanth, A. R, Mathen, J. S, Balagopal, Lakshmi
Format: Artikel
Sprache:eng
Schlagworte:
Combinatorial Chemistry Techniques - methods
Cyanides - chemistry
Cyclization
Heterocyclic Compounds - chemical synthesis
Heterocyclic Compounds - chemistry
Hydrocarbons
Methane - analogs & derivatives
Methane - chemistry
Models, Chemical
Molecular Conformation
Molecular Structure
Stereoisomerism
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Beschreibung
Zusammenfassung:This Account focuses mainly on our recent endeavors in the area of multicomponent reactions (MCRs) involving zwitterionic species generated by the addition of isocyanides and nucleophilic carbenes such as dimethoxycarbene and N-heterocyclic carbenes to activated alkynes. The strategy employed encompasses the interception of 1:1 zwitterionic species, generated in situ with a wide range of electrophiles. The new MCRs developed offer an efficient and convenient entry into several heterocycles of biological and synthetic importance.
ISSN:0001-4842
1520-4898
DOI:10.1021/ar020258p