Biosynthesis of Zeaxanthin via Mevalonate in Paracoccus Species Strain PTA-3335. A Product-Based Retrobiosynthetic Study

Cultures of the zeaxanthin-producing bacterium Paracoccus species strain PTA-3335 (formerly Flavobacterium) were grown with supplements of 13C-labeled glucose. Zeaxanthin was isolated and analyzed by 13C NMR spectroscopy. The data showed that the isoprenoid precursors of zeaxanthin were biosynthesiz...

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Veröffentlicht in:	Journal of organic chemistry 2002-02, Vol.67 (3), p.871-875
Hauptverfasser:	Eisenreich, Wolfgang, Bacher, Adelbert, Berry, Alan, Bretzel, Werner, Hümbelin, Markus, Lopez-Ulibarri, Rual, Mayer, Anne F., Yeliseev, Alexei
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriology beta Carotene - analogs & derivatives beta Carotene - biosynthesis beta Carotene - chemistry Biological and medical sciences Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy Metabolism. Enzymes Mevalonic Acid - metabolism Microbiology Molecular Structure Paracoccus - metabolism Xanthophylls Zeaxanthins
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Beschreibung
Zusammenfassung:	Cultures of the zeaxanthin-producing bacterium Paracoccus species strain PTA-3335 (formerly Flavobacterium) were grown with supplements of 13C-labeled glucose. Zeaxanthin was isolated and analyzed by 13C NMR spectroscopy. The data showed that the isoprenoid precursors of zeaxanthin were biosynthesized via the mevalonate pathway. The microorganism was found to utilize glucose mainly via the Entner−Doudoroff pathway.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo016084r