Sibling rivalry in the E2F family

The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2002-01, Vol.3 (1), p.11-20
Hauptverfasser:	Lees, Jacqueline A, Trimarchi, Jeffrey M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Binding sites Cell Cycle Cell Cycle Proteins - physiology Cell Differentiation Cell Division Chromatin - metabolism Dihydrofolate reductase DNA-Binding Proteins E2F proteins E2F Transcription Factors E2F6 Transcription Factor Enzymes Gene Expression Regulation Humans Kinases Mice Models, Genetic Neoplasms - etiology Protein Structure, Tertiary Proteins Retinoblastoma Retinoblastoma Protein - metabolism Transcription factors Transcription Factors - genetics Transcription Factors - physiology Tumors
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Beschreibung
Zusammenfassung:	The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this 'push-me-pull-you' regulation, and what are its biological consequences?
ISSN:	1471-0072 1471-0080
DOI:	10.1038/nrm714