Spatiotemporal dynamics of damped propagation in excitable cardiac tissue

Compared to steadily propagating waves (SPW), damped waves (DW), another solution to the nonlinear wave equation, are seldom studied. In cardiac tissue after electrical stimulation in an SPW wake, we observe DW with diminished amplitude and velocity that either gradually decrease as the DW dies, or...

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Veröffentlicht in:Physical review letters 2003-11, Vol.91 (20), p.208104-208104, Article 208104
Hauptverfasser: Sidorov, Veniamin Y, Aliev, Rubin R, Woods, Marcella C, Baudenbacher, Franz, Baudenbacher, Petra, Wikswo, John P
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Sprache:eng
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Zusammenfassung:Compared to steadily propagating waves (SPW), damped waves (DW), another solution to the nonlinear wave equation, are seldom studied. In cardiac tissue after electrical stimulation in an SPW wake, we observe DW with diminished amplitude and velocity that either gradually decrease as the DW dies, or exhibit a sharp amplitude increase after a delay to become an SPW. The cardiac DW-SPW transition is a key link in understanding defibrillation and stimulation close to the refractory period, and is ideal for a general study of DW dynamics.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.91.208104