Synthesis and Vasorelaxant Activity of New Coumarin and Furocoumarin Derivatives

We have synthesized a new series of coumarins and furocoumarins and evaluated their vasorelaxant activity in rat aorta rings pre-contracted with noradrenaline or by depolarisation with high KCl. The new furocoumarins relax smooth vascular muscle with a profile similar to that of khellin (a furochrom...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2002-03, Vol.12 (5), p.783-786
Hauptverfasser: Campos-Toimil, Manuel, Orallo, Francisco, Santana, Lourdes, Uriarte, Eugenio
Format: Artikel
Sprache:eng
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Zusammenfassung:We have synthesized a new series of coumarins and furocoumarins and evaluated their vasorelaxant activity in rat aorta rings pre-contracted with noradrenaline or by depolarisation with high KCl. The new furocoumarins relax smooth vascular muscle with a profile similar to that of khellin (a furochromone that directly relaxes smooth muscle) and at a greater potency, suggesting that these compounds have a potential interest for the development of new and more efficient vasodilator drugs. Several coumarin and furocoumarin derivatives showed vasorelaxant activity in rat aorta rings. The new compounds relax smooth vascular muscle with a profile similar to that of khellin and, in the case of furocoumarins, with a greater potency, suggesting that these compounds have a potential interest as vasodilatador drugs.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(02)00015-X