A tyrosine-modified hypocrellin B with affinity for and photodamaging ability towards calf thymus DNA

A tyrosine-modified hypocrellin B with affinity for and photodamaging ability towards calf thymus DNA

An enhanced photodamaging ability towards CT-DNA was achieved in a tyrosine-modified hypocrellin B by improving the affinity of the sensitizer to DNA.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2003-12 (23), p.2900-2901
Hauptverfasser: Xia, Sheng Qin, Zhou, Jia Hong, Chen, Jing Rong, Wang, Xue Song, Zhang, Bao Wen
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Binding Sites
Cattle
DNA - chemistry
DNA - metabolism
DNA Damage - drug effects
DNA Damage - radiation effects
Magnetic Resonance Spectroscopy
Mass Spectrometry
Oxygen - metabolism
Perylene - analogs & derivatives
Perylene - chemical synthesis
Perylene - chemistry
Perylene - metabolism
Perylene - pharmacology
Quinones - chemical synthesis
Quinones - chemistry
Quinones - metabolism
Quinones - pharmacology
Spectrophotometry
Tyrosine - chemistry
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Beschreibung
Zusammenfassung:An enhanced photodamaging ability towards CT-DNA was achieved in a tyrosine-modified hypocrellin B by improving the affinity of the sensitizer to DNA.
ISSN:1359-7345
DOI:10.1039/b309024h