Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation

Gastrol ( 1), together with 10 known phenolic compounds, has been isolated from the MeOH extract of the rhizomes of Gastrodia elata Blume (Orchidaceae), and their structures were elucidated by detailed spectral analyses including by 2D NMR spectroscopic analyses. The relaxant effects of these consti...

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Veröffentlicht in:	Phytochemistry (Oxford) 2002-03, Vol.59 (5), p.513-519
Hauptverfasser:	Hayashi, Junko, Sekine, Toshikazu, Deguchi, Shigeyoshi, Lin, Qing, Horie, Syunji, Tsuchiya, Shizuko, Yano, Shingo, Watanabe, Kazuo, Ikegami, Fumio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chemical constitution Fundamental and applied biological sciences. Psychology Gastrodia elata Gastrodia rhizome Gastrol General pharmacology Guinea Pigs Male Medical sciences Muscle, Smooth - drug effects Orchidaceae Orchidaceae - chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenolic compound Phenols - chemistry Phenols - isolation & purification Phenols - pharmacology Plant physiology and development Postsynaptic nerve Smooth muscle relaxant effect Spectrophotometry, Infrared Spectrophotometry, Ultraviolet
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Zusammenfassung:	Gastrol ( 1), together with 10 known phenolic compounds, has been isolated from the MeOH extract of the rhizomes of Gastrodia elata Blume (Orchidaceae), and their structures were elucidated by detailed spectral analyses including by 2D NMR spectroscopic analyses. The relaxant effects of these constituents on smooth muscle preparations isolated from guinea-pig ileum were also studied in order to reveal their characteristic pharmacological activities. Gastrol ( 1), together with 10 known phenolic compounds, has been isolated from the MeOH extract of the rhizomes of Gastrodia elata. Their structures were elucidated by detailed spectral analyses. The relaxant effects of these constituents on smooth muscle preparations isolated from guinea-pig ileum were also studied.
ISSN:	0031-9422 1873-3700
DOI:	10.1016/S0031-9422(02)00008-0