Determinants of BRAF mutations in primary melanomas

The RAS/mitogen-activated protein kinase pathway sends external growth-promoting signals to the nucleus. BRAF, a critical serine/threonine kinase in this pathway, is frequently activated by somatic mutation in melanoma. Using a cohort of 115 patients with primary invasive melanomas, we show that BRA...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2003-12, Vol.95 (24), p.1878-1880
Hauptverfasser:	MALDONADO, Janet L, FRIDLYAND, Jane, PATEL, Hetal, JAIN, Ajay N, BUSAM, Klaus, KAGESHITA, Toshiro, ONO, Tomomichi, ALBERTSON, Donna G, PINKEL, Dan, BASTIAN, Boris C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Cancer Cohort Studies Dermatology Female Humans Male Medical sciences Melanoma - etiology Melanoma - genetics Middle Aged Mutation Neoplasm Invasiveness Oncogene Proteins - genetics Proteins Proto-Oncogene Proteins B-raf Skin Neoplasms - etiology Skin Neoplasms - genetics Sunlight - adverse effects Tumors of the skin and soft tissue. Premalignant lesions
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