Determinants of BRAF mutations in primary melanomas

Determinants of BRAF mutations in primary melanomas

The RAS/mitogen-activated protein kinase pathway sends external growth-promoting signals to the nucleus. BRAF, a critical serine/threonine kinase in this pathway, is frequently activated by somatic mutation in melanoma. Using a cohort of 115 patients with primary invasive melanomas, we show that BRA...

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Veröffentlicht in:JNCI : Journal of the National Cancer Institute 2003-12, Vol.95 (24), p.1878-1880
Hauptverfasser: MALDONADO, Janet L, FRIDLYAND, Jane, PATEL, Hetal, JAIN, Ajay N, BUSAM, Klaus, KAGESHITA, Toshiro, ONO, Tomomichi, ALBERTSON, Donna G, PINKEL, Dan, BASTIAN, Boris C
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Biological and medical sciences
Cancer
Cohort Studies
Dermatology
Female
Humans
Male
Medical sciences
Melanoma - etiology
Melanoma - genetics
Middle Aged
Mutation
Neoplasm Invasiveness
Oncogene Proteins - genetics
Proteins
Proto-Oncogene Proteins B-raf
Skin Neoplasms - etiology
Skin Neoplasms - genetics
Sunlight - adverse effects
Tumors of the skin and soft tissue. Premalignant lesions
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Zusammenfassung:The RAS/mitogen-activated protein kinase pathway sends external growth-promoting signals to the nucleus. BRAF, a critical serine/threonine kinase in this pathway, is frequently activated by somatic mutation in melanoma. Using a cohort of 115 patients with primary invasive melanomas, we show that BRAF mutations are statistically significantly more common in melanomas occurring on skin subject to intermittent sun exposure than elsewhere (23 of 43 patients; P
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/djg123