Recent Developments of Transition-State Analogue Glycosidase Inhibitors of Non-Natural Product Origin

In the past decade several fundamentally new types of synthetic inhibitors have emerged that are very potent and which have led to new insight in the glycoside cleavage process. Lillelund et al cover this work, limiting itself to cover all new glycosidase inhibitor structures that appeared since 1990 of non-natural product origin, provided they can be regarded as transition-state analogues of the gycoside cleavage process.