Peripheral blood leucocytes ornithine decarboxylase activity in chronic myeloid leukemia patients: prognostic and therapeutic implications

Leukocytes ornithine decarboxylase (ODC) activity was measured in normal individuals and in patients with chronic myeloid leukemia (CML) in chronic phase (CML-CP) as well as in accelerated phase (CML-AP), with an aim to examine the role of ODC activity in prognostic evaluation of CML patients. Our r...

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Veröffentlicht in:	Leukemia research 2002-04, Vol.26 (4), p.349-354
Hauptverfasser:	Tripathi, Anil K, Chaturvedi, Rupesh, Ahmad, Rizwan, Asim, Mohd, Sawlani, Kamal K, Singh, Ram L, Tekwani, Babu L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biological and medical sciences Biomarkers, Tumor CML Female Hematologic and hematopoietic diseases Humans Interferon alpha Leukemia, Myelogenous, Chronic, BCR-ABL Positive - blood Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocytes - enzymology Leukocytes - pathology Male Medical sciences Middle Aged ODC Ornithine decarboxylase Ornithine Decarboxylase - analysis Predictive Value of Tests Prognosis Prognostic marker Up-Regulation
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Zusammenfassung:	Leukocytes ornithine decarboxylase (ODC) activity was measured in normal individuals and in patients with chronic myeloid leukemia (CML) in chronic phase (CML-CP) as well as in accelerated phase (CML-AP), with an aim to examine the role of ODC activity in prognostic evaluation of CML patients. Our results showed that ODC activity was significantly higher in CML-CP (41.02±25.57 nmol/h per 10 7 cells, P
ISSN:	0145-2126 1873-5835
DOI:	10.1016/S0145-2126(01)00142-4