Synthesis of the Liposidomycin Diazepanone Nucleoside

The synthesis of the liposidomycin degradation product 4 from d-glucose establishes its stereochemistry as 5‘S,6‘S and, by incorporation of the earlier diazepanone relative stereochemical assignment, establishes the absolute stereochemistry of the liposidomycins 1 and 2 as 5‘S,6‘S,2‘ ‘‘S,3‘ ‘ ‘ S....

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Veröffentlicht in:	Organic letters 2002-02, Vol.4 (4), p.603-606
Hauptverfasser:	Knapp, Spencer, Morriello, Gregori J, Doss, George A
Format:	Artikel
Sprache:	eng
Schlagworte:	Azepines - chemical synthesis Cyclization Enzyme Inhibitors - chemical synthesis Magnetic Resonance Spectroscopy Models, Molecular Peptidyl Transferases - antagonists & inhibitors Uracil - analogs & derivatives Uracil - chemical synthesis
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Beschreibung
Zusammenfassung:	The synthesis of the liposidomycin degradation product 4 from d-glucose establishes its stereochemistry as 5‘S,6‘S and, by incorporation of the earlier diazepanone relative stereochemical assignment, establishes the absolute stereochemistry of the liposidomycins 1 and 2 as 5‘S,6‘S,2‘ ‘‘S,3‘ ‘ ‘ S.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol0102904