Carbohydrate-Based Mimetics in Drug Design:  Sugar Amino Acids and Carbohydrate Scaffolds

Carbohydrate-Based Mimetics in Drug Design:  Sugar Amino Acids and Carbohydrate Scaffolds

Gruner et al review the synthesis of sugar amino acids (SAAs), their incorporation in peptidic or saccharidic structures, and their potential use in medicinal chemistry. Besides their immediate intrinsic different pharmacological properties, SAAs can be used as building blocks for the preparation of...

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Veröffentlicht in:Chemical reviews 2002-02, Vol.102 (2), p.491-514
Hauptverfasser: Gruner, Sibylle A. W, Locardi, Elsa, Lohof, Elisabeth, Kessler, Horst
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Amino Acids - chemical synthesis
Amino Acids - chemistry
Biochemistry
Carbohydrate Sequence
Carbohydrates
Carbohydrates - chemistry
Drug Design
Molecular Sequence Data
Oligosaccharides - chemical synthesis
Oligosaccharides - chemistry
Pharmacology
Sugar Acids - chemical synthesis
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Zusammenfassung:Gruner et al review the synthesis of sugar amino acids (SAAs), their incorporation in peptidic or saccharidic structures, and their potential use in medicinal chemistry. Besides their immediate intrinsic different pharmacological properties, SAAs can be used as building blocks for the preparation of modified analogues of biologically active peptides and/or oligosacharides.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr0004409