Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon
In an effort to establish distinct phylogenetic values for the major GABA(A) receptor subunit mRNAs (alpha(1), beta(2) and gamma(2)) in the telencephalon, the cellular expression capacity of these mRNAs was evaluated in this brain region of two distantly related mammals (hedgehog and rat). Applicati...
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| Veröffentlicht in: | Experimental brain research 2002-02, Vol.142 (4), p.504-511 |
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| container_title | Experimental brain research |
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| creator | Facciolo, Rosa Maria Alo', Raffaella Canonaco, Marcello Franzoni, Maria Fosca |
| description | In an effort to establish distinct phylogenetic values for the major GABA(A) receptor subunit mRNAs (alpha(1), beta(2) and gamma(2)) in the telencephalon, the cellular expression capacity of these mRNAs was evaluated in this brain region of two distantly related mammals (hedgehog and rat). Application of emulsion hybridization histochemistry and quantitative film autoradiography approaches allowed us to detect elevated ( P |
| doi_str_mv | 10.1007/s00221-001-0972-x |
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Application of emulsion hybridization histochemistry and quantitative film autoradiography approaches allowed us to detect elevated ( P<0.01) beta(2) mRNA levels in primitive telencephalic neuronal populations such as those of the glomerular olfactory layer of the hedgehog. Conversely, notable levels of the alpha(1)-subunit mRNA were also registered for the higher telencephalic regions such as the oriens-pyramidalis layer of the hippocampus although elevated levels were mostly obtained for the rat. Interestingly, it was the high number of giant pyramidal neurons that were actively involved in the expression of this subunit. A similar pattern was also detected for pyramidal-like cells of the rat lateral amygdala region expressing the gamma(2)-subunit mRNA. Taken together, these results suggest an early phylogenetic success of GABAergic neuronal mechanisms relying mainly on elevated beta(2)-subunit levels. On the other hand, elevated quantities of gamma(2)- and, above all, of alpha(1)-subunit mRNAs in the rat seem instead to be related to the highly advanced behavioral and mnemonic strategies that are under the control of these telencephalic regions.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/s00221-001-0972-x</identifier><identifier>PMID: 11845246</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; Female ; Hedgehogs ; Phylogeny ; Protein Subunits ; Rats ; Rats, Sprague-Dawley ; Receptors, GABA-A - analysis ; Receptors, GABA-A - genetics ; RNA, Messenger - analysis ; RNA, Messenger - genetics ; Telencephalon - metabolism</subject><ispartof>Experimental brain research, 2002-02, Vol.142 (4), p.504-511</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c229t-dec8308c37af96922f52d823a86e8de2bc1d49e7bdeaa7022b843d2a464586813</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11845246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Facciolo, Rosa Maria</creatorcontrib><creatorcontrib>Alo', Raffaella</creatorcontrib><creatorcontrib>Canonaco, Marcello</creatorcontrib><creatorcontrib>Franzoni, Maria Fosca</creatorcontrib><title>Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><description>In an effort to establish distinct phylogenetic values for the major GABA(A) receptor subunit mRNAs (alpha(1), beta(2) and gamma(2)) in the telencephalon, the cellular expression capacity of these mRNAs was evaluated in this brain region of two distantly related mammals (hedgehog and rat). Application of emulsion hybridization histochemistry and quantitative film autoradiography approaches allowed us to detect elevated ( P<0.01) beta(2) mRNA levels in primitive telencephalic neuronal populations such as those of the glomerular olfactory layer of the hedgehog. Conversely, notable levels of the alpha(1)-subunit mRNA were also registered for the higher telencephalic regions such as the oriens-pyramidalis layer of the hippocampus although elevated levels were mostly obtained for the rat. Interestingly, it was the high number of giant pyramidal neurons that were actively involved in the expression of this subunit. A similar pattern was also detected for pyramidal-like cells of the rat lateral amygdala region expressing the gamma(2)-subunit mRNA. Taken together, these results suggest an early phylogenetic success of GABAergic neuronal mechanisms relying mainly on elevated beta(2)-subunit levels. On the other hand, elevated quantities of gamma(2)- and, above all, of alpha(1)-subunit mRNAs in the rat seem instead to be related to the highly advanced behavioral and mnemonic strategies that are under the control of these telencephalic regions.</description><subject>Animals</subject><subject>Female</subject><subject>Hedgehogs</subject><subject>Phylogeny</subject><subject>Protein Subunits</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, GABA-A - analysis</subject><subject>Receptors, GABA-A - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - genetics</subject><subject>Telencephalon - metabolism</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRbK3-AC-yJ9FDdL-abI6x1CoUBdGDp2WzmdiUzYe7ibT_3q0teBiGmXnfF-ZB6JKSO0pIcu8JYYxGhIRKExZtjtCYCs4iSkl8jMbhICIhaTpCZ96vdyNPyCkaUSrFlIl4jD7n2tkt7lZb235BA31l8I-2A-C2xP0KcK3XrcOL7CG7yW6xAwNdHxZ-yIem6nH99pJ5XDV_2h4sNEGw0rZtztFJqa2Hi0OfoI_H-fvsKVq-Lp5n2TIyjKV9VICRnEjDE12mccpYOWWFZFzLGGQBLDe0ECkkeQFaJ-HfXApeMC1iMZWxpHyCrve5nWu_B_C9qitvwFrdQDt4lVAhJJNxENK90LjWewel6lxVa7dVlKgdT7XnqQInteOpNsFzdQgf8hqKf8cBIP8FASJwUA</recordid><startdate>200202</startdate><enddate>200202</enddate><creator>Facciolo, Rosa Maria</creator><creator>Alo', Raffaella</creator><creator>Canonaco, Marcello</creator><creator>Franzoni, Maria Fosca</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200202</creationdate><title>Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon</title><author>Facciolo, Rosa Maria ; Alo', Raffaella ; Canonaco, Marcello ; Franzoni, Maria Fosca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c229t-dec8308c37af96922f52d823a86e8de2bc1d49e7bdeaa7022b843d2a464586813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Female</topic><topic>Hedgehogs</topic><topic>Phylogeny</topic><topic>Protein Subunits</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, GABA-A - analysis</topic><topic>Receptors, GABA-A - genetics</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - genetics</topic><topic>Telencephalon - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Facciolo, Rosa Maria</creatorcontrib><creatorcontrib>Alo', Raffaella</creatorcontrib><creatorcontrib>Canonaco, Marcello</creatorcontrib><creatorcontrib>Franzoni, Maria Fosca</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Facciolo, Rosa Maria</au><au>Alo', Raffaella</au><au>Canonaco, Marcello</au><au>Franzoni, Maria Fosca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon</atitle><jtitle>Experimental brain research</jtitle><addtitle>Exp Brain Res</addtitle><date>2002-02</date><risdate>2002</risdate><volume>142</volume><issue>4</issue><spage>504</spage><epage>511</epage><pages>504-511</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><abstract>In an effort to establish distinct phylogenetic values for the major GABA(A) receptor subunit mRNAs (alpha(1), beta(2) and gamma(2)) in the telencephalon, the cellular expression capacity of these mRNAs was evaluated in this brain region of two distantly related mammals (hedgehog and rat). Application of emulsion hybridization histochemistry and quantitative film autoradiography approaches allowed us to detect elevated ( P<0.01) beta(2) mRNA levels in primitive telencephalic neuronal populations such as those of the glomerular olfactory layer of the hedgehog. Conversely, notable levels of the alpha(1)-subunit mRNA were also registered for the higher telencephalic regions such as the oriens-pyramidalis layer of the hippocampus although elevated levels were mostly obtained for the rat. Interestingly, it was the high number of giant pyramidal neurons that were actively involved in the expression of this subunit. A similar pattern was also detected for pyramidal-like cells of the rat lateral amygdala region expressing the gamma(2)-subunit mRNA. Taken together, these results suggest an early phylogenetic success of GABAergic neuronal mechanisms relying mainly on elevated beta(2)-subunit levels. On the other hand, elevated quantities of gamma(2)- and, above all, of alpha(1)-subunit mRNAs in the rat seem instead to be related to the highly advanced behavioral and mnemonic strategies that are under the control of these telencephalic regions.</abstract><cop>Germany</cop><pmid>11845246</pmid><doi>10.1007/s00221-001-0972-x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Experimental brain research, 2002-02, Vol.142 (4), p.504-511 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Female Hedgehogs Phylogeny Protein Subunits Rats Rats, Sprague-Dawley Receptors, GABA-A - analysis Receptors, GABA-A - genetics RNA, Messenger - analysis RNA, Messenger - genetics Telencephalon - metabolism |
| title | Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon |
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