Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon

Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon

In an effort to establish distinct phylogenetic values for the major GABA(A) receptor subunit mRNAs (alpha(1), beta(2) and gamma(2)) in the telencephalon, the cellular expression capacity of these mRNAs was evaluated in this brain region of two distantly related mammals (hedgehog and rat). Applicati...

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Veröffentlicht in:Experimental brain research 2002-02, Vol.142 (4), p.504-511
Hauptverfasser: Facciolo, Rosa Maria, Alo', Raffaella, Canonaco, Marcello, Franzoni, Maria Fosca
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Female
Hedgehogs
Phylogeny
Protein Subunits
Rats
Rats, Sprague-Dawley
Receptors, GABA-A - analysis
Receptors, GABA-A - genetics
RNA, Messenger - analysis
RNA, Messenger - genetics
Telencephalon - metabolism
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Zusammenfassung:In an effort to establish distinct phylogenetic values for the major GABA(A) receptor subunit mRNAs (alpha(1), beta(2) and gamma(2)) in the telencephalon, the cellular expression capacity of these mRNAs was evaluated in this brain region of two distantly related mammals (hedgehog and rat). Application of emulsion hybridization histochemistry and quantitative film autoradiography approaches allowed us to detect elevated ( P
ISSN:0014-4819
1432-1106
DOI:10.1007/s00221-001-0972-x