A Facile One-Pot Synthesis of 4,5-Diaryl-2,2-dimethyl-3(2H)-furanones

An efficient and practical one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones has been achieved from 1,2-diarylethanones and 2-bromoisobutyryl cyanide in the presence of excess base, by employing the ‘hard soft acid base’ principle. The reaction scope of 2-bromoisobutyryl cyanide could be...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2002-04, Vol.10 (4), p.1137-1142
Hauptverfasser:	Lee, Ki-Wha, Choi, Young Hoon, Joo, Yung Hyup, Kim, Jin Kwan, Shin, Song Seok, Byun, Young Joo, Kim, Yeonjoon, Chung, Shin
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Chemistry Cyclooxygenase Inhibitors - chemical synthesis Exact sciences and technology Furans - chemical synthesis Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Ketones Organic chemistry Preparations and properties
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Zusammenfassung:	An efficient and practical one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones has been achieved from 1,2-diarylethanones and 2-bromoisobutyryl cyanide in the presence of excess base, by employing the ‘hard soft acid base’ principle. The reaction scope of 2-bromoisobutyryl cyanide could be expanded to prepare a variety of 2,2-dimethyl-3(2H)-furanone derivatives other than 4,5-diaryl-2,2-dimethyl-3(2H)-furanones. An efficient and practical one-pot synthesis of 4,5-diaryl-2,2-dimethyl-3(2H)-furanones has been achieved from 1,2-diarylethanones and 2-bromoisobutyryl cyanide in the presence of excess base.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/S0968-0896(01)00388-1