Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism
We present the results of a study using vibrational circular dichroism (VCD) for (+)‐1, which furnished an unambiguous determination of its absolute configuration as S. The most abundant conformation of (+)‐1 in CDCl3 solution was also established. Chirality 14:215–219, 2002. © 2002 Wiley‐Liss, Inc....
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| Veröffentlicht in: | Chirality (New York, N.Y.) N.Y.), 2002, Vol.14 (2-3), p.215-219 |
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| container_title | Chirality (New York, N.Y.) |
| container_volume | 14 |
| creator | Dyatkin, Alexey B. Freedman, Teresa B. Cao, Xiaolin Dukor, Rina K. Maryanoff, Bruce E. Maryanoff, Cynthia A. Matthews, Jay M. Shah, Rekha D. Nafie, Laurence A. |
| description | We present the results of a study using vibrational circular dichroism (VCD) for (+)‐1, which furnished an unambiguous determination of its absolute configuration as S. The most abundant conformation of (+)‐1 in CDCl3 solution was also established. Chirality 14:215–219, 2002. © 2002 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/chir.10058 |
| format | Article |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | absolute configuration Antidiuretic Hormone Receptor Antagonists benzodiazepine Benzodiazepines - chemistry Circular Dichroism conformation Molecular Conformation Solvents Spectrophotometry, Infrared vibrational circular dichroism |
| title | Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism |
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