Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism

Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism

We present the results of a study using vibrational circular dichroism (VCD) for (+)‐1, which furnished an unambiguous determination of its absolute configuration as S. The most abundant conformation of (+)‐1 in CDCl3 solution was also established. Chirality 14:215–219, 2002. © 2002 Wiley‐Liss, Inc....

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Veröffentlicht in:Chirality (New York, N.Y.) N.Y.), 2002, Vol.14 (2-3), p.215-219
Hauptverfasser: Dyatkin, Alexey B., Freedman, Teresa B., Cao, Xiaolin, Dukor, Rina K., Maryanoff, Bruce E., Maryanoff, Cynthia A., Matthews, Jay M., Shah, Rekha D., Nafie, Laurence A.
Format: Artikel
Sprache:eng
Schlagworte:
absolute configuration
Antidiuretic Hormone Receptor Antagonists
benzodiazepine
Benzodiazepines - chemistry
Circular Dichroism
conformation
Molecular Conformation
Solvents
Spectrophotometry, Infrared
vibrational circular dichroism
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Zusammenfassung:We present the results of a study using vibrational circular dichroism (VCD) for (+)‐1, which furnished an unambiguous determination of its absolute configuration as S. The most abundant conformation of (+)‐1 in CDCl3 solution was also established. Chirality 14:215–219, 2002. © 2002 Wiley‐Liss, Inc.
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.10058