Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-a]pyrimidine

Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-a]pyrimidine

Imidazo[1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle.

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Veröffentlicht in:Organic letters 2003-12, Vol.5 (25), p.4835-4837
Hauptverfasser: Li, Wenjie, Nelson, Dorian P, Jensen, Mark S, Hoerrner, R. Scott, Javadi, Gary J, Cai, Dongwei, Larsen, Robert D
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container_end_page 4837
container_issue 25
container_start_page 4835
container_title Organic letters
container_volume 5
creator Li, Wenjie
Nelson, Dorian P
Jensen, Mark S
Hoerrner, R. Scott
Javadi, Gary J
Cai, Dongwei
Larsen, Robert D
description Imidazo[1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle.
doi_str_mv 10.1021/ol035878k
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title Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-a]pyrimidine
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