Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-a]pyrimidine

Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-a]pyrimidine

Imidazo[1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle.

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Veröffentlicht in:Organic letters 2003-12, Vol.5 (25), p.4835-4837
Hauptverfasser: Li, Wenjie, Nelson, Dorian P, Jensen, Mark S, Hoerrner, R. Scott, Javadi, Gary J, Cai, Dongwei, Larsen, Robert D
Format: Artikel
Sprache:eng
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Zusammenfassung:Imidazo[1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol035878k