Biologic strategies for the therapy of intervertebral disc degeneration

Recent advances in tissue engineering have led to promising new approaches for the biologic treatment of disc degeneration. At present, there is no effective therapy for disc degeneration, a condition which results in large healthcare and socio-economic costs. This article will examine the current approaches used in biologic therapies for disc degeneration, including cell-based tissue engineering, gene therapy and the application of mesenchymal stem cells, and discuss their therapeutic potential, as demonstrated in animal models and experimental studies to date.