Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala

The behavioral effects of direct injection of the neuropeptide Y (NPY) Y2 receptor agonist C2-NPY into the basolateral nucleus of the amygdala (BLA) was assessed in rats utilizing the social interaction test (SI). C2-NPY decreased SI time in a dose-dependent manner with a significant change observed...

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Veröffentlicht in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2002-03, Vol.71 (3), p.419-423
Hauptverfasser: Sajdyk, Tammy J, Schober, Douglas A, Smiley, David L, Gehlert, Donald R
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Sprache:eng
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Zusammenfassung:The behavioral effects of direct injection of the neuropeptide Y (NPY) Y2 receptor agonist C2-NPY into the basolateral nucleus of the amygdala (BLA) was assessed in rats utilizing the social interaction test (SI). C2-NPY decreased SI time in a dose-dependent manner with a significant change observed at a dose of 80 pmol/100 nl. The anxiogenic effects produced by intra-amygdalar C2-NPY injections were reversed with intraperitoneal administration of alprazolam (1 mg/kg), a known anxiolytic. These findings support the hypothesis that Y2 receptors are involved in the regulation of the anxiety response.
ISSN:0091-3057
DOI:10.1016/S0091-3057(01)00679-7