Efficient Route to 1,3-Di-N-imidazolylbenzene. A Comparison of Monodentate vs Bidentate Carbenes in Pd-Catalyzed Cross Coupling
A new bis(carbene) ligand architecture has been developed and was evaluated in the Suzuki−Miyaura cross-coupling reaction of various aryl halides with phenylboronic acid. Several new bis(carbene) ligands were tested in different carbene:Pd ratios. Pd(OAc)2 and Pd2(dba)3 were compared for efficiency...
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| Veröffentlicht in: | Organic letters 2003-12, Vol.5 (25), p.4847-4849 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A new bis(carbene) ligand architecture has been developed and was evaluated in the Suzuki−Miyaura cross-coupling reaction of various aryl halides with phenylboronic acid. Several new bis(carbene) ligands were tested in different carbene:Pd ratios. Pd(OAc)2 and Pd2(dba)3 were compared for efficiency as a Pd source. It was found that the Pd(OAc)2/bis(carbene) system formed a catalyst for the activation of chlorobenzene. |
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| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.1021/ol035906z |