Antisense transcripts in the human genome

Antisense transcripts in the human genome

By a systematic search of vertebrate mRNA sequences, we have identified a surprisingly large number of human antisense transcripts. These data suggest that regulation of gene expression by antisense and double-stranded RNAs could be a common phenomenon in mammalian cells. The identification of large...

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Veröffentlicht in:Trends in genetics 2002-02, Vol.18 (2), p.63-65
Hauptverfasser: Lehner, Ben, Williams, Gary, Campbell, R.Duncan, Sanderson, Christopher M.
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Animals
antisense transcripts
Chromosome Mapping
Databases, Nucleic Acid
DNA Repair
DNA, Antisense
double-stranded RNA
Gene Expression Regulation
gene regulation
gene silencing
Genome, Human
Humans
Mammals - genetics
Proteins - genetics
Proteins - metabolism
regulatory RNA
RNA, Messenger - genetics
RNAi
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Beschreibung
Zusammenfassung:By a systematic search of vertebrate mRNA sequences, we have identified a surprisingly large number of human antisense transcripts. These data suggest that regulation of gene expression by antisense and double-stranded RNAs could be a common phenomenon in mammalian cells. The identification of large numbers of natural antisense transcripts (NATs) suggests that antisense regulation of gene expression could be a common phenomenon in mammalian cells.
ISSN:0168-9525
DOI:10.1016/S0168-9525(02)02598-2