New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template
Based on the 7-OH-2-(aminomethyl)chroman dopamine D(2) template (2) is described the preparation and resolution of two bioisosteric analogues. The benzimidazol-2-one derivative (6) had similar affinity to the known indolone derivative (4).
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2002-02, Vol.12 (3), p.271-274 |
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| container_end_page | 274 |
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| container_issue | 3 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 12 |
| creator | Mewshaw, Richard E Zhao, Rulin Shi, Xiaojie Marquis, Karen Brennan, Julie A Mazandarani, Hossein Coupet, Joseph Andree, Terrance H |
| description | Based on the 7-OH-2-(aminomethyl)chroman dopamine D(2) template (2) is described the preparation and resolution of two bioisosteric analogues. The benzimidazol-2-one derivative (6) had similar affinity to the known indolone derivative (4). |
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| ispartof | Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.271-274 |
| issn | 0960-894X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Benzopyrans - chemical synthesis Benzopyrans - chemistry Dopamine Agonists - chemical synthesis Dopamine Agonists - chemistry Models, Structural Receptors, Dopamine D2 - administration & dosage Receptors, Dopamine D2 - chemistry Structure-Activity Relationship Templates, Genetic |
| title | New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template |
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