New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template

Based on the 7-OH-2-(aminomethyl)chroman dopamine D(2) template (2) is described the preparation and resolution of two bioisosteric analogues. The benzimidazol-2-one derivative (6) had similar affinity to the known indolone derivative (4).

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2002-02, Vol.12 (3), p.271-274
Hauptverfasser:	Mewshaw, Richard E, Zhao, Rulin, Shi, Xiaojie, Marquis, Karen, Brennan, Julie A, Mazandarani, Hossein, Coupet, Joseph, Andree, Terrance H
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzopyrans - chemical synthesis Benzopyrans - chemistry Dopamine Agonists - chemical synthesis Dopamine Agonists - chemistry Models, Structural Receptors, Dopamine D2 - administration & dosage Receptors, Dopamine D2 - chemistry Structure-Activity Relationship Templates, Genetic
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Beschreibung
Zusammenfassung:	Based on the 7-OH-2-(aminomethyl)chroman dopamine D(2) template (2) is described the preparation and resolution of two bioisosteric analogues. The benzimidazol-2-one derivative (6) had similar affinity to the known indolone derivative (4).
ISSN:	0960-894X