Antitumor Polycyclic Acridines. 8. Synthesis and Telomerase-Inhibitory Activity of Methylated Pentacyclic Acridinium Salts

Two short routes to novel methylated pentacyclic quinoacridinium salts have been devised. New compounds display telomerase-inhibitory potency (

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2002-01, Vol.45 (3), p.590-597
Hauptverfasser:	Heald, Robert A, Modi, Chetna, Cookson, Jenny C, Hutchinson, Ian, Laughton, Charles A, Gowan, Sharon M, Kelland, Lloyd R, Stevens, Malcolm F. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - chemical synthesis Acridines - chemistry Acridines - metabolism Acridines - pharmacology Antineoplastic agents Biological and medical sciences Cell Nucleus - metabolism Crystallography, X-Ray DNA - chemistry Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Flow Cytometry General aspects Humans Magnetic Resonance Spectroscopy Medical sciences Microscopy, Confocal Models, Molecular Pharmacology. Drug treatments Solubility Structure-Activity Relationship Telomerase - antagonists & inhibitors Telomerase - chemistry Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Two short routes to novel methylated pentacyclic quinoacridinium salts have been devised. New compounds display telomerase-inhibitory potency (
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm011015q