Synthesis and Biological Evaluation of Ebselen and Its Acyclic Derivatives

Five ebselen and three acyclic ebselen derivatives were synthesized. These compounds were screened for their glutathione peroxidase (GSH Px)-like activity and scavenging activity against 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) and peroxynitrite radical. All tested compounds displayed similar significa...

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Veröffentlicht in:Chemical & Pharmaceutical Bulletin 2003, Vol.51(12), pp.1413-1416
Hauptverfasser: Chang, Tsu-Chung, Huang, Mei-Lan, Hsu, Wen-Lin, Hwang, Jing-Min, Hsu, Ling-Yih
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Sprache:eng
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Zusammenfassung:Five ebselen and three acyclic ebselen derivatives were synthesized. These compounds were screened for their glutathione peroxidase (GSH Px)-like activity and scavenging activity against 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) and peroxynitrite radical. All tested compounds displayed similar significant GSH Px-like activity, which are slightly higher than that of ebselen. The peroxynitrite scavenging activity showed that the acyclic allylseleno 4c was five times more potent than ebselen.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.51.1413