Functional and effective frontotemporal connectivity and genetic risk for schizophrenia

Functional neuroimaging and electrophysiologic studies have found disturbed frontotemporal interaction in schizophrenia. We sought to determine whether abnormalities of frontotemporal connectivity are trait markers of genetic risk for schizophrenia. We investigated 64 schizophrenia patients, 79 of t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biological psychiatry (1969) 2003-12, Vol.54 (11), p.1181-1192
Hauptverfasser: Winterer, Georg, Coppola, Richard, Egan, Michael F, Goldberg, Terry E, Weinberger, Daniel R
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1192
container_issue 11
container_start_page 1181
container_title Biological psychiatry (1969)
container_volume 54
creator Winterer, Georg
Coppola, Richard
Egan, Michael F
Goldberg, Terry E
Weinberger, Daniel R
description Functional neuroimaging and electrophysiologic studies have found disturbed frontotemporal interaction in schizophrenia. We sought to determine whether abnormalities of frontotemporal connectivity are trait markers of genetic risk for schizophrenia. We investigated 64 schizophrenia patients, 79 of their clinically unaffected siblings, and 88 unrelated normal controls with an auditory oddball electroencephalogram (EEG) evoked potential paradigm. We measured: 1) frontotemporal event-related EEG-coherence (i.e. a measure of functional connectivity); and 2) we performed structural equation modeling of the effective connectivity between the frontal P300 and temporoparietal P300-amplitude. Schizophrenic patients and their siblings showed a reduction of frontotemporal coherence. At peak activation during the P300 time-window, a negative (“inhibitory”) frontotemporal path coefficient was found in normal controls, whereas a positive coefficient was seen in schizophrenic patients with siblings being intermediate. Intra-class correlations between sib-pairs and relative risk estimates of the applied connectivity measures were non-significant. Topographic correlation matrix analyses suggested that the altered functional and effective frontotemporal connectivity indirectly reflect regional abnormalities of increased activation variance. Impaired interaction of the frontotemporal macro-circuit indirectly reflects genetically determined abnormalities of frontal and temporoparietal microcircuits. The reasons why frontotemporal connectivity appears to be a poor predictor of genetic risk for schizophrenia are discussed.
doi_str_mv 10.1016/S0006-3223(03)00532-8
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71419357</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006322303005328</els_id><sourcerecordid>71419357</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-3fb86e585b9c576f14006af2958edf129bc9a1e13aa1ecde86846cefc018056c3</originalsourceid><addsrcrecordid>eNqFkEtLJDEQgIO46Kz6E5S-uOwees2jk06fRIZ1d0HYg4rHkKmuaLQnGZMeQX-9mQd6XChSFPVVpfgIOWb0J6NMnV1TSlUtOBffqfhBqRS81jtkwnQrat5QvksmH8g--ZrzYylbztke2WeNagTVckLuLpcBRh-DHSob-gqdw1K_YOVSDGMccb6IqTQhhrDu-PF1Td5jwNFDlXx-qlxMVYYH_xYXDwmDt4fki7NDxqNtPiC3l79upn_qq3-__04vrmoQHRtr4WZaodRy1oFslWNNOdk63kmNvWO8m0FnGTJhyws9aqUbBeiAMk2lAnFAvm32LlJ8XmIezdxnwGGwAeMym5Y1rBOyLaDcgJBizgmdWSQ_t-nVMGpWRs3aqFnpMrTEyqjRZe5k-8FyNsf-c2qrsACnW8BmsINLNoDPn5wUolGcFu58w2HR8eIxmQweA2DvUxFr-uj_c8o7t7OT5Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71419357</pqid></control><display><type>article</type><title>Functional and effective frontotemporal connectivity and genetic risk for schizophrenia</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Winterer, Georg ; Coppola, Richard ; Egan, Michael F ; Goldberg, Terry E ; Weinberger, Daniel R</creator><creatorcontrib>Winterer, Georg ; Coppola, Richard ; Egan, Michael F ; Goldberg, Terry E ; Weinberger, Daniel R</creatorcontrib><description>Functional neuroimaging and electrophysiologic studies have found disturbed frontotemporal interaction in schizophrenia. We sought to determine whether abnormalities of frontotemporal connectivity are trait markers of genetic risk for schizophrenia. We investigated 64 schizophrenia patients, 79 of their clinically unaffected siblings, and 88 unrelated normal controls with an auditory oddball electroencephalogram (EEG) evoked potential paradigm. We measured: 1) frontotemporal event-related EEG-coherence (i.e. a measure of functional connectivity); and 2) we performed structural equation modeling of the effective connectivity between the frontal P300 and temporoparietal P300-amplitude. Schizophrenic patients and their siblings showed a reduction of frontotemporal coherence. At peak activation during the P300 time-window, a negative (“inhibitory”) frontotemporal path coefficient was found in normal controls, whereas a positive coefficient was seen in schizophrenic patients with siblings being intermediate. Intra-class correlations between sib-pairs and relative risk estimates of the applied connectivity measures were non-significant. Topographic correlation matrix analyses suggested that the altered functional and effective frontotemporal connectivity indirectly reflect regional abnormalities of increased activation variance. Impaired interaction of the frontotemporal macro-circuit indirectly reflects genetically determined abnormalities of frontal and temporoparietal microcircuits. The reasons why frontotemporal connectivity appears to be a poor predictor of genetic risk for schizophrenia are discussed.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(03)00532-8</identifier><identifier>PMID: 14643085</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Electrodiagnosis. Electric activity recording ; Electroencephalography ; Event-Related Potentials, P300 - physiology ; Female ; Frontal Lobe - physiopathology ; frontotemporal connectivity ; Genetic Predisposition to Disease ; genetics ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Nervous system ; Neural Pathways - physiopathology ; P300 ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Risk Factors ; Schizophrenia ; Schizophrenia - genetics ; Schizophrenia - physiopathology ; Siblings ; Temporal Lobe - physiopathology</subject><ispartof>Biological psychiatry (1969), 2003-12, Vol.54 (11), p.1181-1192</ispartof><rights>2003 Society of Biological Psychiatry</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-3fb86e585b9c576f14006af2958edf129bc9a1e13aa1ecde86846cefc018056c3</citedby><cites>FETCH-LOGICAL-c391t-3fb86e585b9c576f14006af2958edf129bc9a1e13aa1ecde86846cefc018056c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322303005328$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=15334620$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14643085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Winterer, Georg</creatorcontrib><creatorcontrib>Coppola, Richard</creatorcontrib><creatorcontrib>Egan, Michael F</creatorcontrib><creatorcontrib>Goldberg, Terry E</creatorcontrib><creatorcontrib>Weinberger, Daniel R</creatorcontrib><title>Functional and effective frontotemporal connectivity and genetic risk for schizophrenia</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Functional neuroimaging and electrophysiologic studies have found disturbed frontotemporal interaction in schizophrenia. We sought to determine whether abnormalities of frontotemporal connectivity are trait markers of genetic risk for schizophrenia. We investigated 64 schizophrenia patients, 79 of their clinically unaffected siblings, and 88 unrelated normal controls with an auditory oddball electroencephalogram (EEG) evoked potential paradigm. We measured: 1) frontotemporal event-related EEG-coherence (i.e. a measure of functional connectivity); and 2) we performed structural equation modeling of the effective connectivity between the frontal P300 and temporoparietal P300-amplitude. Schizophrenic patients and their siblings showed a reduction of frontotemporal coherence. At peak activation during the P300 time-window, a negative (“inhibitory”) frontotemporal path coefficient was found in normal controls, whereas a positive coefficient was seen in schizophrenic patients with siblings being intermediate. Intra-class correlations between sib-pairs and relative risk estimates of the applied connectivity measures were non-significant. Topographic correlation matrix analyses suggested that the altered functional and effective frontotemporal connectivity indirectly reflect regional abnormalities of increased activation variance. Impaired interaction of the frontotemporal macro-circuit indirectly reflects genetically determined abnormalities of frontal and temporoparietal microcircuits. The reasons why frontotemporal connectivity appears to be a poor predictor of genetic risk for schizophrenia are discussed.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Electroencephalography</subject><subject>Event-Related Potentials, P300 - physiology</subject><subject>Female</subject><subject>Frontal Lobe - physiopathology</subject><subject>frontotemporal connectivity</subject><subject>Genetic Predisposition to Disease</subject><subject>genetics</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Neural Pathways - physiopathology</subject><subject>P300</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Risk Factors</subject><subject>Schizophrenia</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenia - physiopathology</subject><subject>Siblings</subject><subject>Temporal Lobe - physiopathology</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLJDEQgIO46Kz6E5S-uOwees2jk06fRIZ1d0HYg4rHkKmuaLQnGZMeQX-9mQd6XChSFPVVpfgIOWb0J6NMnV1TSlUtOBffqfhBqRS81jtkwnQrat5QvksmH8g--ZrzYylbztke2WeNagTVckLuLpcBRh-DHSob-gqdw1K_YOVSDGMccb6IqTQhhrDu-PF1Td5jwNFDlXx-qlxMVYYH_xYXDwmDt4fki7NDxqNtPiC3l79upn_qq3-__04vrmoQHRtr4WZaodRy1oFslWNNOdk63kmNvWO8m0FnGTJhyws9aqUbBeiAMk2lAnFAvm32LlJ8XmIezdxnwGGwAeMym5Y1rBOyLaDcgJBizgmdWSQ_t-nVMGpWRs3aqFnpMrTEyqjRZe5k-8FyNsf-c2qrsACnW8BmsINLNoDPn5wUolGcFu58w2HR8eIxmQweA2DvUxFr-uj_c8o7t7OT5Q</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Winterer, Georg</creator><creator>Coppola, Richard</creator><creator>Egan, Michael F</creator><creator>Goldberg, Terry E</creator><creator>Weinberger, Daniel R</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Functional and effective frontotemporal connectivity and genetic risk for schizophrenia</title><author>Winterer, Georg ; Coppola, Richard ; Egan, Michael F ; Goldberg, Terry E ; Weinberger, Daniel R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-3fb86e585b9c576f14006af2958edf129bc9a1e13aa1ecde86846cefc018056c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Electroencephalography</topic><topic>Event-Related Potentials, P300 - physiology</topic><topic>Female</topic><topic>Frontal Lobe - physiopathology</topic><topic>frontotemporal connectivity</topic><topic>Genetic Predisposition to Disease</topic><topic>genetics</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Neural Pathways - physiopathology</topic><topic>P300</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Risk Factors</topic><topic>Schizophrenia</topic><topic>Schizophrenia - genetics</topic><topic>Schizophrenia - physiopathology</topic><topic>Siblings</topic><topic>Temporal Lobe - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winterer, Georg</creatorcontrib><creatorcontrib>Coppola, Richard</creatorcontrib><creatorcontrib>Egan, Michael F</creatorcontrib><creatorcontrib>Goldberg, Terry E</creatorcontrib><creatorcontrib>Weinberger, Daniel R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winterer, Georg</au><au>Coppola, Richard</au><au>Egan, Michael F</au><au>Goldberg, Terry E</au><au>Weinberger, Daniel R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional and effective frontotemporal connectivity and genetic risk for schizophrenia</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>54</volume><issue>11</issue><spage>1181</spage><epage>1192</epage><pages>1181-1192</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Functional neuroimaging and electrophysiologic studies have found disturbed frontotemporal interaction in schizophrenia. We sought to determine whether abnormalities of frontotemporal connectivity are trait markers of genetic risk for schizophrenia. We investigated 64 schizophrenia patients, 79 of their clinically unaffected siblings, and 88 unrelated normal controls with an auditory oddball electroencephalogram (EEG) evoked potential paradigm. We measured: 1) frontotemporal event-related EEG-coherence (i.e. a measure of functional connectivity); and 2) we performed structural equation modeling of the effective connectivity between the frontal P300 and temporoparietal P300-amplitude. Schizophrenic patients and their siblings showed a reduction of frontotemporal coherence. At peak activation during the P300 time-window, a negative (“inhibitory”) frontotemporal path coefficient was found in normal controls, whereas a positive coefficient was seen in schizophrenic patients with siblings being intermediate. Intra-class correlations between sib-pairs and relative risk estimates of the applied connectivity measures were non-significant. Topographic correlation matrix analyses suggested that the altered functional and effective frontotemporal connectivity indirectly reflect regional abnormalities of increased activation variance. Impaired interaction of the frontotemporal macro-circuit indirectly reflects genetically determined abnormalities of frontal and temporoparietal microcircuits. The reasons why frontotemporal connectivity appears to be a poor predictor of genetic risk for schizophrenia are discussed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14643085</pmid><doi>10.1016/S0006-3223(03)00532-8</doi><tpages>12</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0006-3223
ispartof Biological psychiatry (1969), 2003-12, Vol.54 (11), p.1181-1192
issn 0006-3223
1873-2402
language eng
recordid cdi_proquest_miscellaneous_71419357
source MEDLINE; Elsevier ScienceDirect Journals
subjects Adult
Adult and adolescent clinical studies
Biological and medical sciences
Electrodiagnosis. Electric activity recording
Electroencephalography
Event-Related Potentials, P300 - physiology
Female
Frontal Lobe - physiopathology
frontotemporal connectivity
Genetic Predisposition to Disease
genetics
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Nervous system
Neural Pathways - physiopathology
P300
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Risk Factors
Schizophrenia
Schizophrenia - genetics
Schizophrenia - physiopathology
Siblings
Temporal Lobe - physiopathology
title Functional and effective frontotemporal connectivity and genetic risk for schizophrenia
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T02%3A26%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20and%20effective%20frontotemporal%20connectivity%20and%20genetic%20risk%20for%20schizophrenia&rft.jtitle=Biological%20psychiatry%20(1969)&rft.au=Winterer,%20Georg&rft.date=2003-12-01&rft.volume=54&rft.issue=11&rft.spage=1181&rft.epage=1192&rft.pages=1181-1192&rft.issn=0006-3223&rft.eissn=1873-2402&rft.coden=BIPCBF&rft_id=info:doi/10.1016/S0006-3223(03)00532-8&rft_dat=%3Cproquest_cross%3E71419357%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71419357&rft_id=info:pmid/14643085&rft_els_id=S0006322303005328&rfr_iscdi=true