Urinary Metabolites of Nobiletin Orally Administered to Rats

During the course of our systematic investigation of the metabolism of flavonoids, the polymethoxyflavone nobiletin, occurring in the fruits of Citrus depressa, was orally administered to rats. The urinary metabolites were separated and identified by three-dimensional HPLC equipped with a photodiode...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2003, Vol.51(12), pp.1426-1428
Hauptverfasser:	Yasuda, Takaaki, Yoshimura, Yukako, Yabuki, Hisako, Nakazawa, Takahiro, Ohsawa, Keisuke, Mimaki, Yoshihiro, Sashida, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Biotransformation Citrus depressa demethylation Flavones Flavonoids - administration & dosage Flavonoids - chemistry Flavonoids - urine General pharmacology Male Medical sciences metabolism nobiletin Pharmacognosy. Homeopathy. Health food Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments polymethoxyflavone Rats Rats, Sprague-Dawley
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Zusammenfassung:	During the course of our systematic investigation of the metabolism of flavonoids, the polymethoxyflavone nobiletin, occurring in the fruits of Citrus depressa, was orally administered to rats. The urinary metabolites were separated and identified by three-dimensional HPLC equipped with a photodiode array detector and the structure was determined by spectroscopic methods to be 4′-hydroxy-3′,5,6,7,8-pentamethoxyflavone (1).
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.51.1426