Acanthamoeba keratitis as a complication of orthokeratology

To present four cases of Acanthamoeba keratitis as a complication of orthokeratology. Observational case report. Four patients with Acanthamoeba keratitis had histories of overnight orthokeratology lens wear of 6 months to 2 years. Three cases were diagnosed with Acanthamoeba keratitis by corneal scraping and one by confocal microscopy examination. The patients were treated with chlorhexidine, metronidazole, and neomycin sulfate, resulting in a rapid resolution of ocular inflammation. Overnight wear of orthokeratology lenses may induce Acanthamoeba keratitis.