Novel Dihydropyrazine Analogues as NPY Antagonists

The dihydropyridine 1 is currently one of the lead compounds in the neuropeptide-Y 1 (NPY-Y 1) receptor antagonist program. Compound 1 is a selective, high affinity ligand at the NPY-Y 1 receptors (IC 50=4.2 nM) in SK-N-MC cells. To further expand the SAR study surrounding this dihydropyridine core structure we succeeded in synthesizing an analogous series of dihydropyrazine derivatives 2 . This structural modification yielded compounds substantially different from the parent molecules in terms of molecular polarization and electron distribution while the overall molecular structure was generally preserved. This altered property should therefore provide us with additional SAR information on the optimal binding requirement with NPY receptors. Efficient synthesis of 2,6-dimethyl dihydropyrazine analogues of 2,6-dimethyl dihydropyridine NPY antagonist was developed.