Whatever happened to cell-bound antibodies? On the overriding influence of dogma

For over 75 years, only humoral antibodies were known to mediate immunological specificity. The apparent absence of these in delayed-type hypersensitivity reactions was perplexing, and the dominant dogma of antibodies led to some curious hypotheses.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2002-02, Vol.3 (2), p.105-108
1. Verfasser:	Silverstein, Arthur M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology - history Antibodies B-Lymphocytes - immunology Biomedical and Life Sciences Biomedicine commentary History, 19th Century History, 20th Century Hypersensitivity Hypersensitivity (delayed) Hypersensitivity, Delayed - immunology Immunity, Cellular - immunology Immunology Infectious Diseases Models, Immunological Receptors, Antigen, T-Cell T-Lymphocytes - immunology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	For over 75 years, only humoral antibodies were known to mediate immunological specificity. The apparent absence of these in delayed-type hypersensitivity reactions was perplexing, and the dominant dogma of antibodies led to some curious hypotheses.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/ni0202-105