In vitro activity of telithromycin against Streptococcus pneumoniae resistant to other antibiotics, including cefotaxime

A total of 407 isolates of Streptococcus pneumoniae, most of which were resistant to one or more antibiotics, were tested for susceptibility to telithromycin and four other agents. Telithromycin was the most active agent tested, with 98% of isolates susceptible to ≤1.0 mg/L. For strains resistant to...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2002-02, Vol.49 (2), p.399-401
Hauptverfasser:	Fuchs, Peter C., Barry, Arthur L., Brown, Steven D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cefotaxime - pharmacology Cephalosporins - pharmacology Drug Evaluation, Preclinical - methods Drug Evaluation, Preclinical - statistics & numerical data Drug Resistance, Multiple, Bacterial Humans Ketolides Macrolides Medical sciences Microbial Sensitivity Tests - statistics & numerical data Pharmacology. Drug treatments Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - isolation & purification
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Zusammenfassung:	A total of 407 isolates of Streptococcus pneumoniae, most of which were resistant to one or more antibiotics, were tested for susceptibility to telithromycin and four other agents. Telithromycin was the most active agent tested, with 98% of isolates susceptible to ≤1.0 mg/L. For strains resistant to the other antibiotics, susceptibility to telithromycin ranged from 98.6% for strains resistant to trimethoprim/sulfamethoxazole to 94.4% for strains resistant to cefotaxime.
ISSN:	0305-7453 1460-2091 1460-2091
DOI:	10.1093/jac/49.2.399