Of mice, men and motor neurons

The use of mouse models has been of particular importance in studying the pathogenesis of amyotrophic lateral sclerosis. Here, we describe both transgenic and classical mutants for which the genetic lesion is known. We draw attention, wherever possible, to pathological factors common to multiple mod...

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Veröffentlicht in:	Trends in Molecular Medicine 2002-02, Vol.8 (2), p.88-92
Hauptverfasser:	Newbery, Helen J, Abbott, Catherine M
Format:	Artikel
Sprache:	eng
Schlagworte:	amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Amyotrophic Lateral Sclerosis - therapy Animals Cytoskeleton - metabolism Disease Models, Animal Endothelial Growth Factors - genetics Endothelial Growth Factors - physiology Genetic Therapy - trends Humans Lymphokines - genetics Lymphokines - physiology Mice Mice, Mutant Strains Mice, Transgenic motor neuron disease Motor Neurons - metabolism Motor Neurons - pathology mouse model neurofilament SOD1 Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1 Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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Zusammenfassung:	The use of mouse models has been of particular importance in studying the pathogenesis of amyotrophic lateral sclerosis. Here, we describe both transgenic and classical mutants for which the genetic lesion is known. We draw attention, wherever possible, to pathological factors common to multiple models. Transgenic, knockout and spontaneous mouse models of amyotrophic lateral sclerosis provide clues to the role of motor neurons and neurofilaments in the pathogenesis of motor neuron disorders.
ISSN:	1471-4914 1471-499X
DOI:	10.1016/S1471-4914(02)02283-9